Divergence of personality from trend of universe.  Exhausts energy charge of soul.  Fatal to happiness.  Most undesirable when prolonged.  Not good for man to be alone.  Planetary isolation affords opportunity to exercise faith. 
Adam and Eve painfully aware of planetary isolation.  Buddhism advocated isolation from objective reality.  Fate of Judas is solemn warning against.  Thomas would have fared better with his fellows.